Bridging Science and Clinical Insight:
Translational Research in Cardiovascular Immunology
Cardiovascular disease is increasingly recognised as an immune-driven condition. My research focuses on understanding how innate immune signalling contributes to cardiac injury, inflammation, and myocardial remodelling following myocardial infarction.
A central focus of my work is the cGAS–STING signalling pathway and its role in inflammatory activation within the heart. I investigate how innate immune responses shape the transition from acute cardiac injury to chronic inflammatory remodelling.
This work examines how interactions between immune cells and resident cardiac cells shape structural and functional adaptation after injury. By identifying pathways that translate inflammatory activation into adverse remodelling, my research aims to uncover mechanisms with therapeutic potential.
Through mechanistic and translational approaches, I seek to bridge experimental discoveries with clinically relevant questions, advancing our understanding of immune-driven cardiovascular disease.
Research Focus
Current Research Directions
Innate immune signalling in cardiovascular disease
cGAS–STING biology and inflammatory activation
Immune-driven myocardial remodelling
Translational cardioimmunology
Immune-cell interactions in myocardial remodelling
Sex-specific inflammatory mechanisms after myocardial infarction
Integration of experimental findings with clinical biomarkers
Identification of novel therapeutic targets
Translational Approach
My work integrates experimental cardiovascular models, molecular pathway analysis, and biomarker-informed clinical data to identify immune-driven mechanisms of cardiac remodelling and heart failure progression.